24,510 XNAS Volume
XNAS 31 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 100,000 | 100,000 | - | - | Employee Stock Option (Right to Buy) | |
| Carolyn D. Beaver | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 24,500 | 24,500 | - | - | Stock Option (Right to Buy) | |
| Hideki Nagao | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 24,500 | 24,500 | - | - | Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 100,000 | 100,000 | - | - | Employee Stock Option (Right to Buy) | |
| Nicole Lemerond | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 24,500 | 24,500 | - | - | Stock Option (Right to Buy) | |
| Carolyn D. Beaver | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Hideki Nagao | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Nicole Lemerond | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2024 | 210,000 | 210,000 | - | - | Employee Stock Option (Right to Buy) | |
| O'Brien Geoffrey | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2024 | 84,000 | 84,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2024 | 157,500 | 157,500 | - | - | Employee Stock Option (Right to Buy) | |
| Nicole Lemerond | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Aug 2023 | 18,333 | 18,333 | - | - | Stock Option (Right to Buy) | |
| Carolyn D. Beaver | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Hideki Nagao | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2023 | 235,125 | 235,125 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2023 | 149,625 | 149,625 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2023 | 76,950 | 76,950 | - | - | Employee Stock Option (Right to Buy) | |
| Hideki Nagao | Director | Sale of securities on an exchange or to another person at price $ 2.25 per share. | 28 Nov 2022 | 6,754 | 0 (0%) | 0% | 2.3 | 15,197 | Common Stock |
| Hideki Nagao | Director | Sale of securities on an exchange or to another person at price $ 2.13 per share. | 21 Nov 2022 | 218 | 6,754 (0%) | 0% | 2.1 | 464 | Common Stock |
| Hideki Nagao | Director | Sale of securities on an exchange or to another person at price $ 2.18 per share. | 21 Nov 2022 | 5,365 | 6,972 (0%) | 0% | 2.2 | 11,696 | Common Stock |
| Hideki Nagao | Director | Sale of securities on an exchange or to another person at price $ 2.18 per share. | 17 Nov 2022 | 309 | 12,337 (0%) | 0% | 2.2 | 674 | Common Stock |
| Carolyn D. Beaver | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Hideki Nagao | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2022 | 302,500 | 302,500 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2022 | 192,500 | 192,500 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2022 | 99,000 | 99,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2021 | 60,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.30 per share. | 23 Aug 2021 | 60,000 | 322,996 (0%) | 0% | 2.3 | 138,000 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.54 per share. | 09 Jul 2021 | 39,583 | 966,933 (2%) | 0% | 2.5 | 100,541 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2021 | 39,583 | 0 | - | - | Employee Stock option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.54 per share. | 24 Jun 2021 | 46,554 | 206,746 (0%) | 0% | 2.5 | 118,247 | Common Stock |
| Kazuko Matsuda | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2021 | 56,250 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2021 | 46,554 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.46 per share. | 24 Jun 2021 | 56,250 | 262,996 (0%) | 0% | 2.5 | 138,375 | Common Stock |
| Carolyn D. Beaver | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Hideki Nagao | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2021 | 11,318 | 14,932 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.54 per share. | 19 May 2021 | 32,000 | 37,000 (0%) | 0% | 2.5 | 81,280 | Common Stock |
| Geoffrey O'Brien | Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.46 per share. | 19 May 2021 | 11,318 | 48,318 (0%) | 0% | 2.5 | 27,842 | Common Stock |
| Geoffrey O'Brien | Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2021 | 32,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Federico C.A. Gaeta | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Apr 2021 | 24,000 | 24,000 | - | - | Employee Stock Option (Right to Buy) | |
| Hideki Nagao | Director | Sale of securities on an exchange or to another person at price $ 7.40 per share. | 11 Mar 2021 | 2,354 | 12,646 (0%) | 0% | 7.4 | 17,420 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Feb 2021 | 86,250 | 0 | - | - | Employee Stock option(Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.46 per share. | 25 Feb 2021 | 86,250 | 927,350 (2%) | 0% | 2.5 | 212,175 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2021 | 495,000 | 495,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2021 | 325,000 | 325,000 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2021 | 99,000 | 99,000 | - | - | Employee Stock Option (Right to Buy) | |
| Carolyn D. Beaver | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Oct 2020 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Hideki Nagao | Director | Sale of securities on an exchange or to another person at price $ 5.78 per share. | 15 Sep 2020 | 1,000 | 15,000 (0%) | 0% | 5.8 | 5,780 | Common Stock |
| Hideki Nagao | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2020 | 15,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Hideki Nagao | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.58 per share. | 06 Aug 2020 | 15,000 | 16,000 (0%) | 0% | 2.6 | 38,700 | Common Stock |
| Hideki Nagao | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Kousuke Nakata | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.13 per share. | 12 Jun 2020 | 20,000 | 160,192 (0%) | 0% | 5.1 | 102,600 | Common Stock |
| Kazuko Matsuda | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2020 | 20,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Apr 2020 | 28,446 | 46,554 | - | - | Employee Stock option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.54 per share. | 08 Apr 2020 | 28,446 | 140,192 (0%) | 0% | 2.5 | 72,253 | Common Stock |
| Kazuko Matsuda | Director, Chief Medical Officer | Purchase of securities on an exchange or from another person at price $ 3.62 per share. | 13 Mar 2020 | 2,000 | 111,746 (0%) | 0% | 3.6 | 7,240 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 3.10 per share. | 12 Mar 2020 | 20,000 | 780,683 (1%) | 0% | 3.1 | 62,000 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2020 | 412,500 | 412,500 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Director, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2020 | 243,750 | 243,750 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2020 | 165,000 | 165,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2019 | 37,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 12 Jun 2019 | 37,000 | 109,457 (0%) | 0% | 4.8 | 177,600 | Common Stock |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Kousuke Nakata | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Yoshio Ishizaka | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Hideki Nagao | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.77 per share. | 13 May 2019 | 1,000 | 1,000 (0%) | 0% | 2.8 | 2,770 | Common Stock |
| Hideki Nagao | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 May 2019 | 1,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.00 per share. | 28 Feb 2019 | 105,000 | 1,040,530 (2%) | 0% | 7 | 735,000 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 80,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 42,500 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 105,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 15,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 105,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 30,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 120,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 100,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 105,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.34 per share. | 28 Feb 2019 | 35,700 | 189,280 (0%) | 0% | 7.3 | 262,038 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.54 per share. | 28 Feb 2019 | 85,000 | 274,280 (0%) | 0% | 2.5 | 215,900 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.46 per share. | 28 Feb 2019 | 63,750 | 338,030 (0%) | 0% | 2.5 | 156,825 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.10 per share. | 28 Feb 2019 | 80,000 | 418,030 (0%) | 0% | 4.1 | 328,000 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.10 per share. | 28 Feb 2019 | 42,500 | 460,530 (1%) | 0% | 4.1 | 174,250 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.64 per share. | 28 Feb 2019 | 105,000 | 565,530 (1%) | 0% | 2.6 | 277,200 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.24 per share. | 28 Feb 2019 | 15,000 | 580,530 (1%) | 0% | 3.2 | 48,600 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.09 per share. | 28 Feb 2019 | 105,000 | 685,530 (1%) | 0% | 3.1 | 324,450 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.91 per share. | 28 Feb 2019 | 30,000 | 715,530 (1%) | 0% | 3.9 | 117,300 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.91 per share. | 28 Feb 2019 | 120,000 | 835,530 (1%) | 0% | 3.9 | 469,200 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.10 per share. | 28 Feb 2019 | 100,000 | 935,530 (2%) | 0% | 6.1 | 610,000 | Common Stock |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 35,700 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 85,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2019 | 63,750 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2019 | 470,000 | 470,000 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2019 | 105,000 | 105,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2019 | 295,000 | 295,000 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2019 | 205,000 | 205,000 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jan 2019 | 41,250 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.20 per share. | 09 Jan 2019 | 41,250 | 153,580 (0%) | 0% | 2.2 | 90,750 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2019 | 18,572 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.20 per share. | 03 Jan 2019 | 18,572 | 759,392 (1%) | 0% | 2.2 | 40,858 | Common Stock |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Kousuke Nakata | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Yoshio Ishizaka | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2018 | 50,003 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.20 per share. | 05 Mar 2018 | 50,003 | 740,594 (1%) | 0% | 2.2 | 110,007 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2018 | 450,000 | 450,000 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2018 | 100,000 | 100,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2018 | 280,000 | 280,000 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2018 | 200,000 | 200,000 | - | - | Employee Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.42 per share. | 03 Jan 2018 | 53,363 | 690,591 (1%) | 0% | 4.4 | 235,864 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2018 | 53,363 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2017 | 48,000 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.42 per share. | 12 Dec 2017 | 48,000 | 108,941 (0%) | 0% | 4.4 | 212,160 | Common Stock |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Nov 2017 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Nov 2017 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Nov 2017 | 21,067 | 0 | - | - | Employee Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.42 per share. | 02 Nov 2017 | 21,067 | 637,228 (1%) | 0% | 4.4 | 93,116 | Common Stock |
| Yoshio Ishizaka | None | Purchase of securities on an exchange or from another person at price $ 5.17 per share. | 21 Aug 2017 | 5,000 | 10,000 (0%) | 0% | 5.2 | 25,850 | Common Stock |
| Kousuke Nakata | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2017 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Yoshio Ishizaka | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2017 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 5.60 per share. | 15 May 2017 | 1,000 | 25,000 (0%) | 0% | 5.6 | 5,600 | Common Stock |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 5.62 per share. | 12 May 2017 | 24,000 | 24,000 (0%) | 0% | 5.6 | 134,880 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2017 | 320,000 | 320,000 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2017 | 120,000 | 120,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2017 | 170,000 | 170,000 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2017 | 115,000 | 115,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 15 Sep 2016 | 11,800 | 81,800 | - | - | Common Stock | |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 Sep 2016 | 10,000 | 70,000 | - | - | Common Stock | |
| Geoffrey O'Brien | Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2016 | 3,300 | 21,700 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Jul 2016 | 3,300 | 5,000 | - | - | Common Stock | |
| Geoffrey O'Brien | Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2016 | 3,300 | 8,300 | - | - | Common Stock | |
| Kousuke Nakata | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2016 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Yoshio Ishizaka | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2016 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | 14 Mar 2016 | 8,400 | 0 | - | - | Warrants (Right to Buy) | ||
| Masatsune Okajima | VP and Head of Japanese Office | 14 Mar 2016 | 8,400 | 51,138 | - | - | Common Stock | ||
| Kazuko Matsuda | Chief Medical Officer | 14 Mar 2016 | 800 | 62,003 | - | - | Common Stock | ||
| Kazuko Matsuda | Chief Medical Officer | 14 Mar 2016 | 800 | 0 | - | - | Warrants (Right to Buy) | ||
| Masatsune Okajima | VP and Head of Japanese Office | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Jan 2016 | 8,400 | 8,400 | - | - | Warrants (Right to Buy) | |
| Kazuko Matsuda | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Jan 2016 | 8,400 | 800 | - | - | Warrants (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2016 | 250,000 | 250,000 | - | - | Employee Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2016 | 120,000 | 120,000 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2016 | 30,000 | 30,000 | - | - | Employee Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2016 | 105,000 | 105,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2016 | 100,000 | 100,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2016 | 125,000 | 125,000 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2016 | 105,000 | 105,000 | - | - | Employee Stock Option (Right to Buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2016 | 30,000 | 30,000 | - | - | Employee Stock Option (Right to Buy) | |
| Kousuke Nakata | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jul 2015 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Yoshio Ishizaka | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jul 2015 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 10 Dec 2014 | 12,000 | 60,000 | - | - | Common Stock | |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2014 | 200,000 | 200,000 | - | - | Employee Stock option (right to buy) | |
| Masatsune Okajima | VP & Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2014 | 105,000 | 105,000 | - | - | Employee Stock option (right to buy) | |
| Masatsune Okajima | VP & Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2014 | 15,000 | 15,000 | - | - | Employee Stock option (right to buy) | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2014 | 120,000 | 120,000 | - | - | Employee Stock option (right to buy) | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2014 | 105,000 | 105,000 | - | - | Employee Stock option (right to buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2014 | 105,000 | 105,000 | - | - | Employee Stock option (right to buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2014 | 15,000 | 15,000 | - | - | Employee Stock option (right to buy) | |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 26 Nov 2014 | 10,000 | 48,000 | - | - | Common Stock | |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Nov 2014 | 13,000 | 38,000 | - | - | Common Stock | |
| Yoshio Ishizaka | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 19 Nov 2014 | 5,000 | 5,000 | - | - | Common Stock | |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Sep 2014 | 10,000 | 25,000 | - | - | Common Stock | |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 03 Sep 2014 | 9,900 | 15,000 | - | - | Common Stock | |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 03 Sep 2014 | 5,000 | 5,000 | - | - | Common Stock | |
| Kousuke Nakata | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 03 Sep 2014 | 100 | 5,100 | - | - | Common Stock | |
| Esther Van Den Boom | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Aug 2014 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Yoshio Ishizaka | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Apr 2014 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Tatsuo Izumi | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 12 Dec 2013 | 70,300 | 600,970 | - | - | Common Stock | |
| Tatsuo Izumi | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 12 Dec 2013 | 970 | 600,000 | - | - | Common Stock | |
| Yuichi Iwaki | Director, President, CEO & Interim CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2013 | 145,000 | 145,000 | - | - | Employee Stock Option (right to buy) | |
| Masatsune Okajima | VP & Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2013 | 80,000 | 80,000 | - | - | Employee Stock Option (right to buy) | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2013 | 80,000 | 80,000 | - | - | Employee Stock Option (right to buy) | |
| Geoffrey O'Brien | Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2013 | 55,000 | 55,000 | - | - | Employee Stock Option (right to buy) | |
| Tatsuo Izumi | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Nov 2013 | 970 | 671,270 | - | - | Common Stock | |
| Tatsuo Izumi | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Nov 2013 | 300 | 670,300 | - | - | Common Stock | |
| Kousuke Nakata | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2013 | 15,000 | 15,000 | - | - | Stock Option (right to buy) | |
| Arlene M. Morris | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 May 2013 | 1,000 | 1,000 | - | - | Common Stock | |
| Arlene M. Morris | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 May 2013 | 7,800 | 8,800 | - | - | Common Stock | |
| Arlene M. Morris | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 May 2013 | 1,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Arlene M. Morris | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 May 2013 | 7,800 | 36,200 | - | - | Stock Option (Right to Buy) | |
| Arlene M. Morris | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 21 May 2013 | 8,800 | 0 | - | - | Common Stock | |
| Michael Coffee | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2013 | 42,500 | 42,500 | - | - | Stock Option (Right to Buy) | |
| Yuichi Iwaki | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2013 | 62,500 | 62,500 | - | - | Stock Option (Right to Buy) | |
| Kirk W. Johnson | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2013 | 42,500 | 42,500 | - | - | Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2013 | 42,500 | 42,500 | - | - | Stock Option (Right to Buy) | |
| Tatsuo Izumi | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 May 2013 | 158,730 | 158,730 | - | - | Common Stock | |
| Tatsuo Izumi | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 May 2013 | 119,047 | 119,047 | - | - | Warrant to Purchase Common Stock | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2013 | 42,500 | 42,500 | - | - | Stock Option (Right to Buy) | |
| Michael Coffee | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2012 | 63,750 | 63,750 | - | - | Stock Option (Right to Buy) | |
| Yuichi Iwaki | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2012 | 86,250 | 86,250 | - | - | Stock Option (Right to Buy) | |
| Kirk W. Johnson | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2012 | 63,750 | 63,750 | - | - | Stock Option (Right to Buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2012 | 63,750 | 63,750 | - | - | Stock Option (Right to Buy) | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2012 | 56,250 | 56,250 | - | - | Stock Option (Right to Buy) | |
| Tatsuo Izumi | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 31 May 2012 | 5,200 | 56,800 | - | - | Common Stock | |
| David D. O'Toole | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 29 May 2012 | 5,000 | 5,000 | - | - | Common Stock | |
| Tatsuo Izumi | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 28 May 2012 | 30,000 | 45,000 | - | - | Common Stock | |
| Tatsuo Izumi | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 28 May 2012 | 6,600 | 51,600 | - | - | Common Stock | |
| Hiroaki Shigeta | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2012 | 1,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Hiroaki Shigeta | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2012 | 14,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Hiroaki Shigeta | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2012 | 30,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Hiroaki Shigeta | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2012 | 1,000 | 1,000 | - | - | Common Stock | |
| Hiroaki Shigeta | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2012 | 44,000 | 45,000 | - | - | Common Stock | |
| David D. O'Toole | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Apr 2012 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Tatsuo Izumi | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Apr 2012 | 15,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Tatsuo Izumi | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Apr 2012 | 15,000 | 15,000 | - | - | Common Stock | |
| Tatsuo Izumi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2011 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Kazuko Matsuda | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2011 | 60,000 | 60,000 | - | - | Employee Stock Option (Right to Buy) | |
| Arlene M. Morris | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jul 2011 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Arlene M. Morris | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jul 2011 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Hiroaki Shigeta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jul 2011 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Hiroaki Shigeta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jul 2011 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| John K.A. Prendergast | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jul 2011 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| John K.A. Prendergast | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jul 2011 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.54 per share. | 13 Jul 2011 | 60,417 | 841,100 (1%) | 0% | 2.5 | 153,459 | Common Stock |
| Yuichi Iwaki | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jul 2011 | 60,417 | 39,583 | - | - | Employee Stock option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jul 2011 | 100,000 | 100,000 | - | - | Employee Stock option (Right to Buy) | |
| Arlene M. Morris | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2011 | 1,000 | 1,000 | - | - | Stock Option (Right to Buy) | |
| Hiroaki Shigeta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2011 | 1,000 | 1,000 | - | - | Stock Option (Right to Buy) | |
| John K.A. Prendergast | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2011 | 1,000 | 1,000 | - | - | Stock Option (Right to Buy) | |
| Jeff W. Himawan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2011 | 1,000 | 1,000 | - | - | Stock Option (Right to Buy) | |
| Yuichi Iwaki | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 29 Mar 2011 | 50,000 | 568,972 (1%) | - | - | Common Stock | |
| Yuichi Iwaki | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 29 Mar 2011 | 50,000 | 50,000 | - | - | Common Stock Warrants (Right to Buy) | |
| Kirk W. Johnson | Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 29 Mar 2011 | 1,700 | 1,700 | - | - | Common Stock Warrants (Right to Buy) | |
| Kirk W. Johnson | Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 29 Mar 2011 | 1,700 | 1,700 (0%) | - | - | Common Stock | |
| Michael Coffee | CBO & Interim CFO | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 29 Mar 2011 | 4,000 | 4,000 | - | - | Common Stock Warrants (Right to Buy) | |
| Michael Coffee | CBO & Interim CFO | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 29 Mar 2011 | 4,000 | 4,000 (0%) | - | - | Common Stock | |
| Michael Coffee | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2010 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| John K.A. Prendergast | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2010 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Alan W. Dunton | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2010 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Jeff W. Himawan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2010 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Arlene M. Morris | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2010 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Hiroaki Shigeta | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2010 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Kirk W. Johnson | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2010 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2010 | 58,600 | 58,600 | - | - | Stock Option (right to buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2010 | 35,700 | 35,700 | - | - | Stock Option (right to buy) | |
| Asako Shintaro | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2010 | 35,700 | 35,700 | - | - | Stock Option (right to buy) | |
| Hiroaki Shigeta | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Sep 2009 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Michael E. Kalafer | Chief Medical Officer | 28 Jul 2009 | 3,437 | 11,563 | - | - | Stock Option (Right to Buy) | ||
| Michael E. Kalafer | Chief Medical Officer | 28 Jul 2009 | 19,586 | 33,714 | - | - | Stock Option (right to buy) | ||
| Michael E. Kalafer | Chief Medical Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 28 Jul 2009 | 3,437 | 12,158 | - | - | Common Stock | |
| Michael E. Kalafer | Chief Medical Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 28 Jul 2009 | 19,586 | 31,744 | - | - | Common Stock | |
| John K.A. Prendergast | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2009 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Alan W. Dunton | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2009 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Jeff W. Himawan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2009 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Arlene M. Morris | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2009 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2009 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 02 Feb 2009 | 1,800 | 643,972 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2009 | 97,500 | 97,500 | - | - | Stock Option (right to buy) | |
| Richard Gammans | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2009 | 60,000 | 60,000 | - | - | Stock Option (right to buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2009 | 41,250 | 41,250 | - | - | Stock Option (right to buy) | |
| Michael E. Kalafer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2009 | 41,250 | 41,250 | - | - | Stock Option (right to buy) | |
| Asako Shintaro | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2009 | 60,000 | 60,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 23 Jan 2009 | 2,200 | 639,322 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 23 Jan 2009 | 1,650 | 640,972 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 23 Jan 2009 | 1,200 | 642,172 | - | - | Common Stock, par vlaue $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 Jan 2009 | 1,071 | 634,922 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 Jan 2009 | 2,200 | 637,122 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 Jan 2009 | 2,000 | 629,851 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 Jan 2009 | 2,000 | 631,851 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 Jan 2009 | 2,000 | 633,851 | - | - | Common Stock, par value $0.001 | |
| Michael E. Kalafer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2008 | 15,000 | 15,000 | - | - | Stock Option (right to buy) | |
| Daniel Vapnek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2008 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| John K.A. Prendergast | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2008 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Alan W. Dunton | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2008 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Jeff W. Himawan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2008 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Arlene M. Morris | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2008 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2008 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2008 | 130,000 | 130,000 | - | - | Stock Option (right to buy) | |
| Richard Gammans | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2008 | 96,000 | 96,000 | - | - | Stock Option (right to buy) | |
| Kenneth W. Locke | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2008 | 39,000 | 39,000 | - | - | Stock Option (right to buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2008 | 48,000 | 48,000 | - | - | Stock Option (right to buy) | |
| Asako Shintaro | VP and Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2008 | 74,000 | 74,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 04 Oct 2007 | 1,300 | 627,851 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 01 Oct 2007 | 730 | 618,581 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 01 Oct 2007 | 2,170 | 620,751 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 01 Oct 2007 | 2,900 | 623,651 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 01 Oct 2007 | 2,900 | 626,551 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | 21 Sep 2007 | 367,828 | 667,828 | - | - | Common Stock, par value $0.001 | ||
| Yuichi Iwaki | Director, Chief Executive Officer | Sale or transfer of securities back to the company at price $ 0.00 per share. | 21 Sep 2007 | 49,977 | 617,851 | - | - | Common Stock, par value $0.001 | |
| Yuichi Iwaki | Director, Chief Executive Officer | 21 Sep 2007 | 367,828 | 0 | - | - | Common Stock Warrant (right to buy) | ||
| Yuichi Iwaki | Director, Chief Executive Officer | Sale or transfer of securities back to the company at price $ 0.00 per share. | 05 May 2007 | 40,000 | 0 | - | - | Nonstatutory Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2007 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | Sale or transfer of securities back to the company at price $ 0.00 per share. | 05 May 2007 | 333,503 | 0 | - | - | Nonstatutory Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2007 | 333,503 | 333,503 | - | - | Employee Stock Option (right to buy) | |
| Daniel Vapnek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2007 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| John K.A. Prendergast | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2007 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Alan W. Dunton | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2007 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Jeff W. Himawan | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2007 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Arlene M. Morris | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2007 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Apr 2007 | 1,000 | 1,000 | - | - | Stock Option (right to buy) | |
| Daniel Vapnek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| John K.A. Prendergast | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 333,503 | 333,503 | - | - | Stock Option (right to buy) | |
| Alan W. Dunton | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Richard Gammans | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 166,752 | 166,752 | - | - | Stock Option (right to buy) | |
| Jeff W. Himawan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Arlene M. Morris | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Kenneth W. Locke | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 145,908 | 145,908 | - | - | Stock Option (right to buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 125,064 | 125,064 | - | - | Stock Option (right to buy) | |
| Asako Shintaro | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Nov 2006 | 125,064 | 125,064 | - | - | Stock Option (right to buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2006 | 150,000 | 150,000 | - | - | Stock Option (right to buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2006 | 250,000 | 250,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | 07 Aug 2006 | 1,500,000 | 3,678,286 | - | - | Common Stock Warrant (right to buy) | ||
| Yuichi Iwaki | Director, Chief Executive Officer | 07 Aug 2006 | 1,500,000 | 3,000,000 | - | - | Common Stock, par value $0.001 | ||
| Yuichi Iwaki | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jul 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jul 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Daniel Vapnek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2006 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| John K.A. Prendergast | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2006 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2006 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Alan W. Dunton | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2006 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Alan W. Dunton | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Arlene M. Morris | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2006 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Arlene M. Morris | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2006 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Acting CEO | 02 Mar 2006 | 1,250,000 | 5,178,286 | - | - | Common Stock Warrant (right to buy) | ||
| Yuichi Iwaki | Director, Acting CEO | 02 Mar 2006 | 1,250,000 | 1,500,000 | - | - | Common Stock, par value $0.001 | ||
| Jeff W. Himawan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Jeff W. Himawan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Jeff W. Himawan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2006 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2006 | 150,000 | 150,000 | - | - | Stock Option (right to buy) | |
| Masatsune Okajima | VP and Head of Japanese Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2006 | 250,000 | 250,000 | - | - | Stock Option (right to buy) | |
| Daniel Vapnek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Daniel Vapnek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| John K.A. Prendergast | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| John K.A. Prendergast | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Yuichi Iwaki | Director, Acting CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2006 | 400,000 | 400,000 | - | - | Employee Stock Option (right to buy) | |
| Richard Gammans | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2006 | 400,000 | 400,000 | - | - | Employee Stock Option (right to buy) | |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Hideki Nagao | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Kenneth W. Locke | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2006 | 320,000 | 320,000 | - | - | Employee Stock Option (right to buy) | |
| Joji Suzuki | Sr. V.P., Finance & Admin. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2006 | 300,000 | 300,000 | - | - | Employee Stock Option (right to buy) | |
| Richard Gammans | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 200,000 | 200,000 | - | - | Employee Stock Option (right to buy) | |
| Richard Gammans | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 300,000 | 300,000 | - | - | Employee Stock Option (right to buy) | |
| Richard Gammans | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 500,000 | 500,000 | - | - | Employee Stock Option (right to buy) | |
| Kenneth W. Locke | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Kenneth W. Locke | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 225,000 | 225,000 | - | - | Employee Stock Option (right to buy) | |
| Kenneth W. Locke | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 375,000 | 375,000 | - | - | Employee Stock Option (right to buy) | |
| Joji Suzuki | Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Joji Suzuki | Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 225,000 | 225,000 | - | - | Employee Stock Option (right to buy) | |
| Joji Suzuki | Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 375,000 | 375,000 | - | - | Employee Stock Option (right to buy) | |
| Asako Shintaro | V.P., Accounting & Admin. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 100,000 | 100,000 | - | - | Employee Stock Option (right to buy) | |
| Asako Shintaro | V.P., Accounting & Admin. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Asako Shintaro | V.P., Accounting & Admin. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 250,000 | 250,000 | - | - | Employee Stock Option (right to buy) | |
| Asako Shintaro | V.P., Accounting & Admin. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2005 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Daniel Vapnek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Sep 2005 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| John K.A. Prendergast | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Sep 2005 | 10,000 | 10,000 | - | - | Stock Option (right to buy) |